 | Professor, Dept. Medical Microbiology & Immunology, UW-Madison
1550 Linden Drive
(608) 262-3161
3303 Microbial Sciences Building
ljknoll@wisc.edu |
https://mmi.wisc.edu/staff/knoll-laura/
- B.A. - 1989; Saint Olaf College; Northfield, MN
- Ph.D. - 1994; Washington University School of Medicine; St. Louis, MO
- Postdoctoral Research- Stanford University; Stanford, CA
Molecular parasitology; Vaccine development for the intracellular parasite
Toxoplasma gondiiOur research centers on studying the host/pathogen interactions of the intracellular parasite
Toxoplasma gondii.
T. gondii is well known for causing encephalitis in immunocompromised patients and is a member of the coccidian family of parasites that include
Plasmodium (causative agent of malaria) and
Cryptosporidium (causative agent of diarrhea). My laboratory
uses the latest technologies, including next generation sequencing and mass spectrometry, to uncover the parasite and host genes that are necessary for the establishment and maintenance of chronic infection in animals
. We then use biochemistry, molecular and cell biology to define the how and why these pathogen and host genes are important.
- Hryckowian ND, Ramírez-Flores CJ, Zinda C, Park SC, Kelty MT, Knoll LJ 2024. Host cell-specific metabolism of linoleic acid controls growth in cell culture. Infection and immunity 92((10)):e0029924 PMC8754478
- Gallego-López GM, Contreras Guzman E, Desa DE, Knoll LJ, Skala MC 2024. Metabolic changes in -infected host cells measured by autofluorescence imaging. mBio 15((8)):e0072724 PMC4081273
- Hryckowian ND, Zinda C, Park SC, Kelty MT, Knoll LJ 2024. Host cell-specific metabolism of linoleic acid controls growth in cell culture. bioRxiv : the preprint server for biology : PMC8754478
- Hryckowian ND, Knoll LJ 2024. Sex in a dish: high-efficiency Toxoplasma pre-sexual development. Trends in parasitology 40((3)):209-210 PMC6701743
- John SV, Seim GL, Erazo-Flores BJ, Steill J, Freeman J, Votava JA, Arp NL, Qing X, Stewart R, Knoll LJ, Fan J 2024. Macrophages undergo functionally significant reprograming of nucleotide metabolism upon classical activation. bioRxiv : the preprint server for biology : PMC4055029
- Owens LA, Friant S, Martorelli Di Genova B, Knoll LJ, Contreras M, Noya-Alarcon O, Dominguez-Bello MG, Goldberg TL 2024. VESPA: an optimized protocol for accurate metabarcoding-based characterization of vertebrate eukaryotic endosymbiont and parasite assemblages. Nature communications 15((1)):402 PMC2777867
- Ramírez-Flores CJ, Erazo Flores BJ, Tibabuzo Perdomo AM, Barnes KL, Wilson SK, Mendoza Cavazos C, Knoll LJ 2023. A lipoxygenase-like enzyme is necessary for virulence and changes localization associated with the host immune response. mBio 14((5)):e0127923 PMC3156017
- Gallego-López GM, Guzman EC, Knoll LJ, Skala M 2023. Metabolic changes to host cells with infection. bioRxiv : the preprint server for biology : PMC4311848
- Mendoza Cavazos C, Heredia MY, Owens LA, Knoll LJ 2023. Using To Model Fecal-Oral Transmission of in Mice. mBio 14((1)):e0300822 PMC2696921
- Humayun M, Ayuso JM, Park KY, Martorelli Di Genova B, Skala MC, Kerr SC, Knoll LJ, Beebe DJ 2022. Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system. Science advances 8((18)):eabm8012 PMC9075809
- View all Publications @ PubMed
